Piperazine → HCID 11641246、化合物
反応式
Cl[C:2]1[C:3]2[S:13][C:12]3[N:14]=[C:15]([C:19]4[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=4)[CH:16]=[C:17]([CH3:18])[C:11]=3[C:4]=2[N:5]=[C:6]([CH2:8][CH2:9][CH3:10])[N:7]=1.[NH:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>O1CCCC1>[CH3:28][O:27][C:21]1[CH:20]=[C:19]([C:15]2[CH:16]=[C:17]([CH3:18])[C:11]3[C:4]4[N:5]=[C:6]([CH2:8][CH2:9][CH3:10])[N:7]=[C:2]([N:29]5[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]5)[C:3]=4[S:13][C:12]=3[N:14]=2)[CH:24]=[CH:23][C:22]=1[O:25][CH3:26]参加物
4
実験手順
0.42 g (1.0 mmol) 4-chloro-7-(3,4-dimethoxyphenyl)-9-methyl-2-propyl-pyrido-[3′,2′:4,5]thieno[3,2-d]pyrimidine and 0.37 g (4.3 mmol) piperazine in 8 ml tetrahydrofuran are stirred at room temperature for 4 h. Having removed the solvent, the residue is suspended in 10 ml water and sucked off. The residue is suspended in about 50 ml dichloromethane and filtrated. The filtrate is washed with a total of 30 ml water, dried on sodium sulfate and the solvent is removed. The residue is recrystallized from ethyl acetate. 0.17 g (37%) of the title substance is obtained.