Potassium Carbonate → (S)-6-Fluoro-3-[1-(3-hydroxy-2-methylpropyl)-4-piperidinyl]-1,2-benzisothiazole fumarate

HRID 55658

反応式

HRID 55658 の反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6]([CH:9]3[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]3)=[N:7][S:8][C:4]=2[CH:3]=1.Br[CH2:18][C@H:19]([CH3:22])[CH2:20][OH:21].C([O-])([O-])=O.[K+].[K+].[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33]>CC(C)=O.S([O-])([O-])(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC.CCOC(C)=O.O.CC#N>[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33].[F:1][C:2]1[CH:16]=[CH:15][C:5]2[C:6]([CH:9]3[CH2:10][CH2:11][N:12]([CH2:18][C@H:19]([CH3:22])[CH2:20][OH:21])[CH2:13][CH2:14]3)=[N:7][S:8][C:4]=2[CH:3]=1

参加物

10

反応物 4

HCID 11430Potassium CarbonateHCID 444972Fumaric AcidHCID 10441885(R)-(-)-3-Bromo-2-methyl-1-propanolHCID 185049766-Fluoro-3-(4-piperidinyl)-1,2-benzisothiazole

生成物 1

HCID 22868569(S)-6-Fluoro-3-[1-(3-hydroxy-2-methylpropyl)-4-piperidinyl]-1,2-benzisothiazole fumarate収率 69.1%

試薬・触媒・溶媒 5

HCID 11433187Bis(tetrabutylammonium) sulphate触媒HCID 180Acetone溶媒HCID 962Water溶媒2 回HCID 6342Acetonitrile溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 6-fluoro-3-(4-piperidinyl)-1,2-benzisothiazole (4.6 g, 20 mmol), (R)-(-)-3-bromo-2-methyl-1-propanol (3.0 g, 20 mmol), K2CO3 (2.7 g, 20 mmol), tetrabutylammonium sulfate (0.058 g), CH3CN (95 ml) and H2O (19 ml) was stirred and refluxed for 4.5 hours. After standing at ambient temperature for 16 hours, the reaction was poured into H2O, and subsequent extractive workup of the aqueous with EtOAc yielded 6.8 g of a partially solidified oil. The product was purified by flash chromatography on silica gel, eluting the column with CH2Cl2, then 2% MeOH--CH2Cl2 and finally 5% MeOH--CH2Cl2. Concentration of the appropriate fractions yielded 5.2 g of a waxy solid. The solid was dissolved in acetone and fumaric acid (1.9 g, 1.0 eq) was added and the reaction briefly heated at reflux. The resultant fumarate salt precipitated from solution yielding 4.8 g of white solid. The compound was recrystallized from acetonitrile to yield 3.1 g (36%) of the alcohol as a white solid, m.p.=151°-153° C.

後処理

  1. temperaturerefluxed for 4.5 hours
  2. customyielded 6.8 g of a partially solidified oil
  3. customThe product was purified by flash chromatography on silica gel
  4. washeluting the column with CH2Cl2
  5. customConcentration of the appropriate fractions yielded 5.2 g of a waxy solid
  6. customthe reaction
  7. temperaturebriefly heated
  8. temperatureat reflux
  9. customThe resultant fumarate salt precipitated from solution

出典と根拠

ORDレコード
ord-6c01c24e89ac4d93a2d83773fd14c6d7
出典データセット
uspto-grants-1997_04
特許番号
US05624927

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