Trifluoroacetic acid → HCID 42610782、化合物

HRID 556805ノート

反応式

HRID 556805 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[CH:21]=[C:20]([NH:22][C:23]3[CH:28]=[N:27][C:26]([C:29]#[N:30])=[CH:25][N:24]=3)[N:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=[O:34]>>[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[N:17]=[CH:18][N:19]=[C:20]([NH:22][C:23]3[N:24]=[CH:25][C:26]([C:29]([NH2:30])=[O:34])=[N:27][CH:28]=3)[CH:21]=2)[CH2:10][CH2:9]1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 66746317Tert-butyl-4-((6-(5-cyanopyrazin-2-ylamino)pyrimidin-4-ylamino)methyl)-piperidine-1-carboxylate

生成物 1

HCID 42610782HCID 42610782、化合物収率 15%

反応条件

温度
82 °C

実験手順

A mixture of tert-butyl-4-((6-(5-cyanopyrazin-2-ylamino)pyrimidin-4-ylamino)methyl)-piperidine-1-carboxylate (0.15 mmol) and trifluoroacetic acid was heated at 82° C. for 4 hours. The solution was evaporated to dryness and the residue was purified by preparative HPLC to give 5-(6-(piperidin-4-ylmethylamino)pyrimidin-4-ylamino)pyrazine-2-carboxamide (7.36 mg, 15%).

後処理

  1. customThe solution was evaporated to dryness
  2. customthe residue was purified by preparative HPLC

出典と根拠

ORDレコード
ord-d65d416cc06a4ebcac0afb723a3c4252
出典データセット
uspto-grants-2011_11
特許番号
US08058045B2

反応ノート

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