Thioglycolic Acid → 4-(Carboxymethylthio)-3-oxobutanoic acid

HRID 557110

反応式

HRID 557110 の反応式
[SH:1][CH2:2][C:3]([OH:5])=[O:4].Cl[CH2:7][C:8](=[O:13])[CH2:9][C:10]([OH:12])=[O:11]>CO>[C:3]([CH2:2][S:1][CH2:7][C:8](=[O:13])[CH2:9][C:10]([OH:12])=[O:11])([OH:5])=[O:4]

参加物

4

反応物 2

HCID 1133Thioglycolic AcidHCID 119720Butanoic acid, 4-chloro-3-oxo-

生成物 1

HCID 574805774-(Carboxymethylthio)-3-oxobutanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
23.5 °C

実験手順

To a round bottom flask containing mercaptoacetic acid (0.1 mol) dissolved in methanol (25 mL) is added 4-chloro-3-oxobutanoic acid (0.1 mol). The resulting mixture is heated at reflux temperature for about 2 hours. When the reaction is complete, the mixture is allowed to cool to room temperature (22-25° C.). Volatiles are removed under vacuum and the resulting residue is purified by column chromatography to yield 4-(carboxymethylthio)-3-oxobutanoic acid.

後処理

  1. temperatureThe resulting mixture is heated
  2. temperatureat reflux temperature for about 2 hours
  3. customVolatiles are removed under vacuum
  4. customthe resulting residue is purified by column chromatography

出典と根拠

ORDレコード
ord-cdc3abd1d7a244a59e3873e929f9236c
出典データセット
uspto-grants-2011_11
特許番号
US08058313B2

関連ノート

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