関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Thioglycolic Acid | HCID 1133 | — |
| 反応物 | Butanoic acid, 4-chloro-3-oxo- | HCID 119720 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(Carboxymethylthio)-3-oxobutanoic acid | HCID 57480577 | — |
反応手順
To a round bottom flask containing mercaptoacetic acid (0.1 mol) dissolved in methanol (25 mL) is added 4-chloro-3-oxobutanoic acid (0.1 mol). The resulting mixture is heated at reflux temperature for about 2 hours. When the reaction is complete, the mixture is allowed to cool to room temperature (22-25° C.). Volatiles are removed under vacuum and the resulting residue is purified by column chromatography to yield 4-(carboxymethylthio)-3-oxobutanoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08058313B2 |
|---|
| 出典データセット | uspto-grants-2011_11 |
|---|
| ORD ID | ord-cdc3abd1d7a244a59e3873e929f9236c |
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| 出典メモ | uspto-grants-2011_11 |
|---|
