Methyl iodide → 6,7-Dimethoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

HRID 557129ノート

反応式

HRID 557129 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]([CH3:15])[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:7][C:6]2=[S:22].[I:23][CH3:24]>>[I-:23].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N+:9]([CH3:15])=[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[N:7]=[C:6]2[S:22][CH3:24]

参加物

3

反応物 2

HCID 6328Methyl iodideHCID 866355306,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione

生成物 1

HCID 669913456,7-Dimethoxy-1-methyl-4-methylsulfanyl-2-phenyl-quinazolin-1-ium iodide

実験手順

1.00 g (3.20 mmol) 6,7-Dimethoxy-1-methyl-2-phenyl-1H-quinazolin-4-thione was slowly added to 5 ml (80 mmol) iodomethane at 0° C. and stirred for 1 h at room temperature. The solution was filtrated and the residue washed with ethyl ether and dichloromethane.

後処理

  1. filtrationThe solution was filtrated
  2. washthe residue washed with ethyl ether and dichloromethane

出典と根拠

ORDレコード
ord-29a46963b21a4491bf07eb420f74de6a
出典データセット
uspto-grants-2011_11
特許番号
US08058431B2

反応ノート

読み込み中…