Chloroform → 6-Methoxy-1-methyl-2-phenyl-1H-quinazolin-4-one

反応式

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:12][CH3:13])=[C:7]([CH:11]=1)[C:8]([NH2:10])=[O:9].C(Cl)(=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.Cl[CH:24](Cl)Cl>>[CH3:1][O:2][C:3]1[CH:11]=[C:7]2[C:6](=[CH:5][CH:4]=1)[N:12]([CH3:24])[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:10][C:8]2=[O:9]

参加物

反応物 3

HCID 6212Chloroform

HCID 7412Benzoyl chloride

HCID 669916645-Methoxy-2-methylamino-benzamide

生成物 1

HCID 669907996-Methoxy-1-methyl-2-phenyl-1H-quinazolin-4-one

実験手順

1.00 g (5.55 mmol) 5-Methoxy-2-methylamino-benzamide were dissolved in 25 ml trichloromethane and 2.34 g (1.93 ml, 16.6 mmol) benzoyl chloride were added. The mixture was boiled for 90 min. After filtration the residue was dissolved in trichloromethane and saturated sodium bicarbonate solution. The organic solution was dried over magnesium sulfate and evaporated under vacuum.