Thionyl Chloride → 2-AMino-N-(2,3-dihydro-benzo[1,4]dioxin-6-ylMethyl)-acetaMide

HRID 557205ノート

反応式

HRID 557205 の反応式
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11]O)[C:5]=2[O:4][CH2:3][CH2:2]1.S(Cl)([Cl:15])=O>ClCCl>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH2:11][Cl:15])[C:5]=2[O:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 27761822,3-dihydro-1,4-benzodioxin-5-ylmethanol

生成物 1

HCID 224188622-AMino-N-(2,3-dihydro-benzo[1,4]dioxin-6-ylMethyl)-acetaMide収率 100.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Dissolve (2,3-Dihydrobenzo[1,4]dioxin-5-yl)methanol (1.8 g, 10.8 mmol) in dichloromethane (15 mL). Add neat thionyl chloride (2 mL, 27.4 mmol) dropwise to the stirring reaction mixture at 25° C. under nitrogen. Stir the reaction for 15 minutes and concentrate under reduced pressure to obtain 2.0 g (100%) of the desired compound as a yellow oil.

後処理

  1. customdropwise to the stirring reaction mixture at 25° C. under nitrogen
  2. customthe reaction for 15 minutes
  3. concentrationconcentrate under reduced pressure

出典と根拠

ORDレコード
ord-10dae19a35ec4d2bbd9e5a5b9665a124
出典データセット
uspto-grants-2011_11
特許番号
US08058425B2

反応ノート

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