Hydrochloric Acid → 1-(3,5-Dibromophenyl)ethanone
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]([OH:7])=O.C[Li].[CH3:14]COC(C)=O.Cl>CCOCC>[Br:11][C:9]1[CH:8]=[C:4]([C:5](=[O:7])[CH3:14])[CH:3]=[C:2]([Br:1])[CH:10]=1参加物
6
反応条件
- 温度
- 0 °C
実験手順
To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyllithium (1.6M in Et2O; 12.3 mL, 19.6 mmol) dropwise. The reaction was stirred at 0° C. for 2 hours, and then worked-up with EtOAc and 10% aqueous HCl. The crude material was purified by silica gel chromatography to give the title compound.
後処理
- customThe crude material was purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-39c48f6d7e864b28b0186d9de9d4f0ef
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08058300B2
反応ノート
読み込み中…