Hydrochloric Acid → 1-(3,5-Dibromophenyl)ethanone

HRID 557673

反応式

HRID 557673 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]([OH:7])=O.C[Li].[CH3:14]COC(C)=O.Cl>CCOCC>[Br:11][C:9]1[CH:8]=[C:4]([C:5](=[O:7])[CH3:14])[CH:3]=[C:2]([Br:1])[CH:10]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 12063Benzoic acid, 3,5-dibromo-HCID 178418348HCID 178418348、化合物

生成物 1

HCID 6218251-(3,5-Dibromophenyl)ethanone

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyllithium (1.6M in Et2O; 12.3 mL, 19.6 mmol) dropwise. The reaction was stirred at 0° C. for 2 hours, and then worked-up with EtOAc and 10% aqueous HCl. The crude material was purified by silica gel chromatography to give the title compound.

後処理

  1. customThe crude material was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-39c48f6d7e864b28b0186d9de9d4f0ef
出典データセット
uspto-grants-2011_11
特許番号
US08058300B2

関連ノート

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