Trifluoroacetic acid → 2,2-Dimethyl-3-(piperidine-4-yl)-propionic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:21])[C:4]([CH3:20])([CH3:19])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:21])[C:4]([CH3:19])([CH3:20])[CH2:5][CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1参加物
4
実験手順
2,2-dimethyl-3-(N-Boc-piperidine-4-yl)-propionic acid methyl ester (598 mg) from above was dissolved in methylene chloride (2 mL) and trifluoroacetic acid (1 mL) was added. The mixture was stirred at room temperature for 1 hr and the solvents were evaporated. The mixture was partitioned between ether and sodium hydroxide solution (1N). The organic layer was washed with brine and dried. Evaporation of solvents gave 2,2-dimethyl-3-(piperidine-4-yl)-propionic acid methyl ester (370 mg) as an oil.
後処理
- customthe solvents were evaporated
- customThe mixture was partitioned between ether and sodium hydroxide solution (1N)
- washThe organic layer was washed with brine
- customdried
- customEvaporation of solvents
出典と根拠
- ORDレコード
- ord-47652721ec6d4e26adbdafed4dfb1d06
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08058299B2
反応ノート
読み込み中…