Potassium Hydroxide → 6-Bromo-1-benzothiophene-2-carboxylic acid

HRID 55771

反応式

HRID 55771 の反応式
[Br:1][C:2]1[CH:14]=[CH:13][C:5]2[CH:6]=[C:7]([C:9]([O:11]C)=[O:10])[S:8][C:4]=2[CH:3]=1.[OH-].[K+]>C1COCC1>[Br:1][C:2]1[CH:14]=[CH:13][C:5]2[CH:6]=[C:7]([C:9]([OH:11])=[O:10])[S:8][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 224740786-Bromo-benzo[b]thiophene-2-carboxylic acid methyl ester

生成物 1

HCID 135679806-Bromo-1-benzothiophene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.

後処理

  1. customThe solvent is removed in vacuo
  2. filtrationThe resulting precipitate is filtered off with suction
  3. washwashed with water
  4. customdried in vacuo at 50° C

出典と根拠

ORDレコード
ord-195c3d7f9ab44d679c042dadfc5e6873
出典データセット
uspto-grants-2016_09
特許番号
US09433614B2

関連ノート

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