Hydrochloric Acid → 3-(2-Ethoxyethoxy)propanenitrile
反応式
[CH2:1]([O:3][CH2:4][CH2:5][OH:6])[CH3:2].[C:7](#[N:10])[CH:8]=[CH2:9].Cl>CO>[CH2:1]([O:3][CH2:4][CH2:5][O:6][CH2:9][CH2:8][C:7]#[N:10])[CH3:2]参加物
5
実験手順
To an ice-water cooled mixture of 2-ethoxyethanol (1 g, 11.1 mmol) and Triton B (40% in MeOH, 0.138 g, 0.33 mmol) was added acrylonitrile (0.618 g, 11.6 mmol) and the mixture was stirred at room temperature for 24 hours. It was then neutralized with 0.1 M HCl (3.3 cm3) and extracted with CH2Cl2 (2×10 cm3) The extracts were concentrated under reduced pressure and the residue was Kugelrohr-distilled to give the product 3-(2-ethoxyethoxy)propanenitrile (1.20 g, 75.5%) as a colorless oil, bp 100-130° C./20 Torr.
後処理
- extractionextracted with CH2Cl2 (2×10 cm3) The extracts
- concentrationwere concentrated under reduced pressure
- distillationthe residue was Kugelrohr-distilled
出典と根拠
- ORDレコード
- ord-b2b4cad208c24821b58e1eaa5c9f4808
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08062429B2
反応ノート
読み込み中…