N,N-Dimethylaniline → HCID 57429963、化合物

HRID 558073ノート

反応式

HRID 558073 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH:2]=1.[C:14](Cl)([Cl:16])=[O:15].C1(C)C=CC=CC=1.CN(C)C1C=CC=CC=1>O1CCCC1>[Cl:16][C:14]([O:13][C:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH:8]=1)=[O:15]

参加物

6

反応物 4

HCID 949N,N-DimethylanilineHCID 1140TolueneHCID 6371PhosgeneHCID 129379483-(Pyridin-3-yl)phenol

生成物 1

HCID 57429963HCID 57429963、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
25 °C

実験手順

A solution of 3-pyridin-3-yl-phenol in tetrahydrofuran was treated with 20% phosgene in toluene (1.0 eq.) at 25° C. The reaction mixture was then treated with N,N-dimethylaniline (1.3 eq) at 0° C. The reaction mixture was stirred at 25° C. over night. The volatiles were removed under reduced pressure. The crude product 3-pyridin-3-yl-phenyl chloroformate was used without further purification.

後処理

  1. customThe volatiles were removed under reduced pressure
  2. customThe crude product 3-pyridin-3-yl-phenyl chloroformate was used without further purification

出典と根拠

ORDレコード
ord-e6726ca4a788492baa5c994eab52bd4b
出典データセット
uspto-grants-2011_11
特許番号
US08063021B2

反応ノート

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