Hydrochloric Acid → 2-(2-Bromo-4-chlorophenyl)-2-fluoroethanamine, hydrochloride

HRID 558113ノート

反応式

HRID 558113 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([F:12])[C:10]#[N:11].C(O)C.Cl>C1COCC1>[ClH:8].[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([F:12])[CH2:10][NH2:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 574450602-(2-Bromo-4-chlorophenyl)-2-fluoroacetonitrile

生成物 1

HCID 1317292842-(2-Bromo-4-chlorophenyl)-2-fluoroethanamine, hydrochloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

Dissolve 2-(2-bromo-4-chlorophenyl)-2-fluoroacetonitrile (2.45 g, 9.86 mmol) in THF (50 mL). Cool the mixture to 0° C., then add BH3-THF complex (1 N, 20 mL, 20 mmol), and stir overnight. Add ethanol (5 mL) and then adjust to acidic with an ethanolic HCl solution. After removing the solvent, add DCM (20 mL) to the solid. Filter and wash with DCM, and dry to give the title compound as the HCl salt. MS (ES) m/z 254 [M+1]+.

後処理

  1. customAfter removing the solvent
  2. additionadd DCM (20 mL) to the solid
  3. filtrationFilter
  4. washwash with DCM
  5. customdry

出典と根拠

ORDレコード
ord-f3dd02536dd14319a89d307f450df901
出典データセット
uspto-grants-2011_11
特許番号
US08063035B2

反応ノート

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