Borane;tetrahydrofuran → 2-(2-Bromo-4-fluorophenyl)-2-methylpropan-1-amine

HRID 558116ノート

反応式

HRID 558116 の反応式
B.C1COCC1.[Br:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[C:15]([CH3:19])([CH3:18])[C:16]#[N:17]>C1COCC1>[Br:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[C:15]([CH3:19])([CH3:18])[CH2:16][NH2:17]

参加物

4

反応物 2

HCID 2723981Borane;tetrahydrofuranHCID 574450632-(2-Bromo-4-fluorophenyl)-2-methylpropanenitrile

生成物 1

HCID 574450652-(2-Bromo-4-fluorophenyl)-2-methylpropan-1-amine収率 99%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Add borane-THF complex (2 M in THF, 10 mL, 20 mmol) to a stirred solution of 2-(2-bromo-4-fluoro-phenyl)-2-methyl-propionitrile (0.8 g, 3.30 mmol) in 10 mL of THF at 0° C. Stir the mixture at 0° C. to RT over the weekend. Quench the reaction with diluted ammonium hydroxide. Extract the product with chloroform. Dry the organic phase over sodium sulfate and concentrate to give the title compound (0.8 g, 99%). MS (ES) m/z 246/248 [M+1]+.

後処理

  1. customQuench
  2. customthe reaction with diluted ammonium hydroxide
  3. extractionExtract the product with chloroform
  4. dry with materialDry the organic phase over sodium sulfate
  5. concentrationconcentrate

出典と根拠

ORDレコード
ord-e0a86ba2cea449d8aaf894b0330cb5f9
出典データセット
uspto-grants-2011_11
特許番号
US08063035B2

反応ノート

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