Triethylamine → HCID 25071457、化合物

HRID 558452

反応式

HRID 558452 の反応式
C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.Cl.Cl.[NH2:36][C:37]1[N:45]=[C:44]([O:46][CH2:47][CH2:48][CH2:49][CH3:50])[N:43]=[C:42]2[C:38]=1[NH:39][C:40](=[O:62])[N:41]2[CH2:51][CH2:52][CH2:53][NH:54][CH2:55][C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1.CCN(CC)CC.[CH3:70][O:71][C:72](=[O:78])[CH2:73][CH2:74][C:75](O)=[O:76]>CN(C=O)C.CO>[NH2:36][C:37]1[N:45]=[C:44]([O:46][CH2:47][CH2:48][CH2:49][CH3:50])[N:43]=[C:42]2[C:38]=1[NH:39][C:40](=[O:62])[N:41]2[CH2:51][CH2:52][CH2:53][N:54]([CH2:55][C:56]1[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=1)[C:75](=[O:76])[CH2:74][CH2:73][C:72]([O:71][CH3:70])=[O:78]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 77487monoMethyl succinateHCID 2724699PyBOPHCID 1317292856-Amino-9-[3-(benzylamino)propyl]-2-butoxy-7,9-dihydro-8H-purin-8-one, dihydrochloride

生成物 1

HCID 25071457HCID 25071457、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6228Dimethylformamide溶媒

実験手順

PyBop (0.47 g) was added to a mixture of the product from example 1 step (viii) (0.25 g), Et3N (0.7 ml) and succinic acid monomethyl ester (0.16 g) in DMF (8 ml) and stirred at rt for 4 days. MeOH (10 ml) was added, the solvent evaporated under reduced pressure and the residue purified by RPHPLC, yield 46 mg.

後処理

  1. customthe solvent evaporated under reduced pressure
  2. customthe residue purified by RPHPLC, yield 46 mg

出典と根拠

ORDレコード
ord-01bd19a3c14b44299feb915fed82f286
出典データセット
uspto-grants-2011_11
特許番号
US08063051B2

関連ノート

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