(2-Fluoro-6-nitrophenylamino)acetic acid ethyl ester → 5-Fluoro-1,2,3,4-tetrahydroquinoxalin-2-one

HRID 558941ノート

反応式

HRID 558941 の反応式
C([O:3][C:4](=O)[CH2:5][NH:6][C:7]1[C:12]([N+:13]([O-])=O)=[CH:11][CH:10]=[CH:9][C:8]=1[F:16])C>CO.[Pd]>[F:16][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[NH:6][CH2:5][C:4](=[O:3])[NH:13]2

参加物

4

反応物 1

HCID 67000141(2-Fluoro-6-nitrophenylamino)acetic acid ethyl ester

生成物 1

HCID 229128785-Fluoro-1,2,3,4-tetrahydroquinoxalin-2-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a degassed solution of (2-fluoro-6-nitrophenylamino)acetic acid ethyl ester from Example B2 (2.1 g, 8.7 mmol) in methanol (65 ml) was added palladium on carbon (10%, 600 mg). Hydrogen gas was bubbled through the mixture for 75 mins, filtered through Celite® and reduced in vacuo. The residues was purified by flash chromatography on silica (eluant EtOAc: pet. ether 50:50); yield 1.02 g, 71%.

後処理

  1. customHydrogen gas was bubbled through the mixture for 75 mins
  2. filtrationfiltered through Celite®
  3. customThe residues was purified by flash chromatography on silica (eluant EtOAc: pet. ether 50:50)

出典と根拠

ORDレコード
ord-2bf0be37b7da4756bd9fb922566b27a2
出典データセット
uspto-grants-2011_11
特許番号
US08063038B2

反応ノート

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