Trifluoroacetic acid → {5-Fluoro-4-[2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)benzylcarbamoyl]-2-oxo-3,4-dihydro-2H-quinoxalin-1-yl}acetic acid

HRID 558957ノート

反応式

HRID 558957 の反応式
C([O:5][C:6](=[O:44])[CH2:7][N:8]1[C:17]2[C:12](=[C:13]([F:18])[CH:14]=[CH:15][CH:16]=2)[N:11]([C:19](=[O:42])[NH:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]([N:30]3[CH2:36][CH2:35][CH2:34][CH2:33][C:32]4[CH:37]=[CH:38][CH:39]=[CH:40][C:31]3=4)=[O:29])=[CH:24][C:23]=2[CH3:41])[CH2:10][C:9]1=[O:43])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:18][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:12]=1[N:11]([C:19](=[O:42])[NH:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([N:30]3[CH2:36][CH2:35][CH2:34][CH2:33][C:32]4[CH:37]=[CH:38][CH:39]=[CH:40][C:31]3=4)=[O:29])=[CH:24][C:23]=1[CH3:41])[CH2:10][C:9](=[O:43])[N:8]2[CH2:7][C:6]([OH:44])=[O:5]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59807173{5-Fluoro-4-[2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)-benzylcarbamoyl]-2-oxo-3,4-dihydro-2H-quinoxalin-1-yl}acetic Acid Tert-Butyl Ester

生成物 1

HCID 11570214{5-Fluoro-4-[2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)benzylcarbamoyl]-2-oxo-3,4-dihydro-2H-quinoxalin-1-yl}acetic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of {5-fluoro-4-[2-methyl-4-(2,3,4,5-tetrahydrobenzo[b]azepine-1-carbonyl)benzylcarbamoyl]-2-oxo-3,4-dihydro-2H-quinoxalin-1-yl}acetic acid tert-butyl ester from Example 7B (105 mg, 0.175 mmol) in dichloromethane (4.0 ml) was added trifluoroacetic acid (4.0 ml). The mixture was stirred for 1.5 h, evaporated in vacuo and azeotroped with toluene to give a white solid; yield 95 mg, 100%.

後処理

  1. customevaporated in vacuo
  2. customazeotroped with toluene
  3. customto give a white solid

出典と根拠

ORDレコード
ord-bbb1a2d6a25d4e619e56fc861d79828e
出典データセット
uspto-grants-2011_11
特許番号
US08063038B2

反応ノート

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