1-(2-fluoro-4-nitrophenyl)-1H-imidazole → 3-fluoro-4-(1H-imidazol-1-yl)aniline

HRID 559006ノート

反応式

HRID 559006 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1>CO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1

参加物

4

反応物 1

HCID 53061531-(2-fluoro-4-nitrophenyl)-1H-imidazole

生成物 1

HCID 103749763-fluoro-4-(1H-imidazol-1-yl)aniline収率 88.5%

試薬・触媒・溶媒 2

HCID 887Methanol触媒HCID 23938Palladium触媒

実験手順

A mixture of 1-(2-fluoro-4-nitrophenyl)-1H-imidazole (1.81 g, 8.74 mmol) and Pd—C (10%, 0.200 g) in MeOH (20 mL) (containing 10 drops of 6N HCl) was hydrogenated under balloon H2 overnight. The mixture was filtered through celite. The filtrate was concentrated in vacuo. The residue was dried on vacuum to give 3-fluoro-4-(1H-imidazol-1-yl)benzenamine as a solid (1.37 g). MS 178.3 (M+H)

後処理

  1. customwas hydrogenated under balloon H2 overnight
  2. filtrationThe mixture was filtered through celite
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was dried on vacuum

出典と根拠

ORDレコード
ord-6078d85240214a5da2cf80796eb2eec7
出典データセット
uspto-grants-2011_11
特許番号
US08063058B2

反応ノート

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