8-Hydroxyquinoline → 4-nitro-1-phenyl-1H-pyrazole
反応式
[N+:1]([C:4]1[CH:5]=[N:6][NH:7][CH:8]=1)([O-:3])=[O:2].I[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.OC1C=CC=C2C=1N=CC=C2.C([O-])([O-])=O.[K+].[K+]>CS(C)=O.[Cu]I.O>[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:8]=1)([O-:3])=[O:2]参加物
8
実験手順
A mixture of 4-nitropyrazole (270 mg, 2.38 mmol), iodobenzene (485 mg, 2.38 mmol), 8-hydroxyquinoline (60 mg, 0.41 mmol) and K2CO3 (600 mg, 4.34 mmol) in DMSO (3 mL) was degassed with argon before being charged with CuI (45 mg, 0.23 mmol). The mixture in a sealed tube was heated at 130 C for 20 h. Water was added to induce precipitation. The precipitate was collected to give 4-nitro-1-phenyl-1H-pyrazole (454 mg).
後処理
- customwas degassed with argon
- temperatureThe mixture in a sealed tube was heated at 130 C for 20 h
- customprecipitation
- customThe precipitate was collected
出典と根拠
- ORDレコード
- ord-131a10cc4d3e4901b0ef2f1cd531dace
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063058B2
反応ノート
読み込み中…
