(S)-6-benzyl-6-aza-spiro[2,5]octan-4-ol → (4S)-6-Azaspiro[2.5]octan-4-ol

HRID 559340ノート

反応式

HRID 559340 の反応式
C([N:8]1[CH2:15][CH2:14][C:11]2([CH2:13][CH2:12]2)[C@H:10]([OH:16])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH2:12]1[C:11]2([CH2:14][CH2:15][NH:8][CH2:9][C@H:10]2[OH:16])[CH2:13]1

参加物

4

反応物 1

HCID 25204267(S)-6-benzyl-6-aza-spiro[2,5]octan-4-ol

生成物 1

HCID 44541813(4S)-6-Azaspiro[2.5]octan-4-ol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

100 mg (S)-6-benzyl-6-aza-spiro[2.5]octan-4-ol were dissolved in 1 ml methanol and hydrogenated over palladium on barium sulfate. After de-benzylation (IPC by GC), the catalyst was filtered and the filtrate was concentrated under reduced pressure to provide the title compound. The hydrochloride salt of the title compound can be obtained by treating the aminoalcohol with HCl in ethyl acetate.

後処理

  1. filtrationAfter de-benzylation (IPC by GC), the catalyst was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-bea54a87230f4886bf0b03b93d767af7
出典データセット
uspto-grants-2011_11
特許番号
US08063042B2

反応ノート

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