Methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate → Potassium 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate

HRID 559458ノート

反応式

HRID 559458 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:13][NH:14][CH2:15][C:16]([F:19])([F:18])[F:17])[C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.O([Si](C)(C)C)[K:21]>C1COCC1.CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH2:13][NH:14][CH2:15][C:16]([F:17])([F:18])[F:19])[C:9]([O-:11])=[O:10])=[CH:6][CH:7]=1.[K+:21]

参加物

5

反応物 2

HCID 66617993Methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoateHCID 178504318HCID 178504318、化合物

生成物 1

HCID 66617976Potassium 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate収率 118%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of methyl 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate (235 mg, 0.795 mmol) in THF (3.0 mL) was treated with KOTMS (153 mg, 1.19 mmol) at room temperature. The reaction was allowed to stir 18 hours to completion, and the mixture was diluted with ether. The resulting precipitate was isolated by filtration and placed under high vacuum for two hours to afford the potassium 2-(4-chlorophenyl)-3-(2,2,2-trifluoroethylamino)propanoate (299 mg, 118%, excess salts) as a white solid. LCMS (APCI+) m/z 282.0 [M+H]+.

後処理

  1. customThe resulting precipitate was isolated by filtration
  2. waitplaced under high vacuum for two hours

出典と根拠

ORDレコード
ord-939e30a183684b0faa359451eccc564e
出典データセット
uspto-grants-2011_11
特許番号
US08063050B2

反応ノート

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