2-Aminothiazole → 4-bromo-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][CH:15]=[CH:16][N:17]=1>ClCCl.N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:12][C:13]2[S:14][CH:15]=[CH:16][N:17]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1参加物
5
実験手順
A solution of 4-bromo-benzenesulfonyl chloride (100 mmol) and 2-aminothiazole (100 mmol) in dichloromethane and pyridine (300 mL, 8:2) was stirred for one day. After concentrated in vacuo, the residue was diluted with ethyl acetate (500 mL) and the solution was washed with 1N HCl solution, sat NaHCO3, dried over MgSO4, and concentrated in vacuo. The residue was recrystallized in ethyl acetate to give 4-bromo-N-thiazol-2-yl-benzenesulfonamide (85 mmol) as a white solid.
後処理
- concentrationAfter concentrated in vacuo
- additionthe residue was diluted with ethyl acetate (500 mL)
- washthe solution was washed with 1N HCl solution
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
- customThe residue was recrystallized in ethyl acetate
出典と根拠
- ORDレコード
- ord-cb89c4a71c3349dea7583ac879f71fac
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063080B2
反応ノート
読み込み中…