2-Aminothiazole → 4-bromo-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide

HRID 559499

反応式

HRID 559499 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][CH:15]=[CH:16][N:17]=1>ClCCl.N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:12][C:13]2[S:14][CH:15]=[CH:16][N:17]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 21552-AminothiazoleHCID 7396p-Bromobenzenesulfonyl chloride

生成物 1

HCID 6693044-bromo-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide収率 85%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 4-bromo-benzenesulfonyl chloride (100 mmol) and 2-aminothiazole (100 mmol) in dichloromethane and pyridine (300 mL, 8:2) was stirred for one day. After concentrated in vacuo, the residue was diluted with ethyl acetate (500 mL) and the solution was washed with 1N HCl solution, sat NaHCO3, dried over MgSO4, and concentrated in vacuo. The residue was recrystallized in ethyl acetate to give 4-bromo-N-thiazol-2-yl-benzenesulfonamide (85 mmol) as a white solid.

後処理

  1. concentrationAfter concentrated in vacuo
  2. additionthe residue was diluted with ethyl acetate (500 mL)
  3. washthe solution was washed with 1N HCl solution
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo
  6. customThe residue was recrystallized in ethyl acetate

出典と根拠

ORDレコード
ord-cb89c4a71c3349dea7583ac879f71fac
出典データセット
uspto-grants-2011_11
特許番号
US08063080B2

関連ノート

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