Water → 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid hydrazinocarbonylmethyl-amide

HRID 559685

反応式

CO[C:3](=[O:24])[CH2:4][NH:5][C:6]([C:8]1[C:9]2[CH:16]=[N:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[C:10]=2[CH:11]=[N:12][CH:13]=1)=[O:7].O.[NH2:26][NH2:27].O>CCO>[NH:26]([C:3]([CH2:4][NH:5][C:6]([C:8]1[C:9]2[CH:16]=[N:15][N:14]([C:17]3[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=3)[C:10]=2[CH:11]=[N:12][CH:13]=1)=[O:7])=[O:24])[NH2:27]

参加物

反応条件

温度: 60 °C

実験手順

To a solution of {[1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carbonyl]-amino}-acetic acid methyl ester (0.50 g, 1.5 mmol) in EtOH (6 mL) was added hydrazine hydrate (2 mL) and the mixture was warmed at 60° C. After 18 hours, the mixture was cooled to room temperature and poured into water (100 mL). The solid was collected by filtration to afford 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid hydrazinocarbonylmethyl-amide (purity 90%).

後処理

temperaturethe mixture was cooled to room temperature
filtrationThe solid was collected by filtration

出典と根拠

ORDレコード: ord-26af2523af0647bba78faf8d9da7466c
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08063065B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

関連ノート