2-Bromo-1-(2,4-dichlorophenyl)ethan-1-one → 2-bromo-1-(2,4-dichlorophenyl)ethanone-O-methyloxime

To 4.00 g of 2-bromo-1-(2,4-dichlorophenyl)ethanone in 20 ml of ethanol, 1.25 g of methoxyamine hydrochloride was added, and the mixture was stirred at room temperature for 12 hours. After completion of the reaction, the solvent was evaporated under reduced pressure, and the resulting residue was mixed with 20 ml of water and extracted with ethyl acetate (20 ml×2). The resulting organic layers were combined, washed with water (20 ml×1) and then dried over saturated aqueous sodium chloride and then anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain 3.85 g of the desired crude product as a pale yellow oil. The oil was used in the next step without further purification.

1. customAfter completion of the reaction
2. customthe solvent was evaporated under reduced pressure
3. additionthe resulting residue was mixed with 20 ml of water
4. extractionextracted with ethyl acetate (20 ml×2)
5. washwashed with water (20 ml×1)
6. dry with materialdried over saturated aqueous sodium chloride
7. customanhydrous sodium sulfate, and the solvent was evaporated under reduced pressure

ORDレコード

ord-30e9a61033b64db4abdfb2063d86c16e

出典データセット

uspto-grants-2016_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09434684B2