Acetamide → 6-Methyl-5-(2-methyl-1,3-oxazol-4-yl)-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

HRID 559803

反応式

BrCC([C:5]1[CH:6]=[C:7]([C:23]([NH:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([S:33]([CH3:36])(=[O:35])=[O:34])=[CH:29][CH:28]=2)=[O:24])[C:8](=[O:22])[N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[C:10]=1[CH3:11])=O.[C:37]([NH2:40])(=[O:39])[CH3:38].[C:41]1(C)C(C)=CC=C[CH:46]=1.OS(O)(=O)=O>O.CC#N>[CH3:11][C:10]1[N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:19])[F:20])[CH:13]=2)[C:8](=[O:22])[C:7]([C:23]([NH:25][CH2:26][C:27]2[CH:28]=[CH:29][C:30]([S:33]([CH3:36])(=[O:34])=[O:35])=[CH:31][CH:32]=2)=[O:24])=[CH:6][C:5]=1[C:41]1[N:40]=[C:37]([CH3:38])[O:39][CH:46]=1

参加物

実験手順

A mixture of 5-(bromoacetyl)-6-methyl-N-[4-(methylsulfonyl)benzyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (90 mg, 0.15 mmol) and acetamide (44 mg, 0.75 mmol), xylene (300 μl) and conc. H2SO4 (10 μl) was heated with stirring for 3 h. The reaction was diluted with water and CH3CN and purified on preparative HPLC affording the title compound (37 mg, 45%).

後処理

temperaturewas heated
custompurified on preparative HPLC

出典と根拠

ORDレコード: ord-5c21422ce5234402bdf98dc330ddeb43
出典データセット: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08063073B2

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

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