反応式
[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17](Br)[CH:16]=3)[N:12]([CH:22]([CH3:24])[CH3:23])[C:11]2=[O:25])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:26][S:27]([C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[N:34][CH:35]=1)(=[O:29])=[O:28].C(=O)([O-])[O-].[Na+].[Na+]>O1CCOCC1.O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].ClCCl>[C:1]1([S:7]([N:10]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([C:32]4[CH:33]=[N:34][CH:35]=[C:30]([S:27]([CH3:26])(=[O:29])=[O:28])[CH:31]=4)[CH:16]=3)[N:12]([CH:22]([CH3:24])[CH3:23])[C:11]2=[O:25])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
6
反応物 3
生成物 1
試薬・触媒・溶媒 2
実験手順
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 5-(methylsulfonyl)-3-pyridineboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-3-isopropyl-4-[3-(5-methanesulfonyl-pyridin-3-yl)-phenyl]-imidazolidin-2-one as a light yellow oil. MS: 499.9 ([M+H]+)
出典と根拠
- ORDレコード
- ord-00c4d5b050cf4dd8af4ed6cf4aa12d90
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063088B2
関連ノート
読み込み中…