化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Carbonate → 1-Benzenesulfonyl-4-(2'-chloro-5'-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-Chloro-5-fluorobenzeneboronic acid | HCID 22648116 | — |
| 反応物 | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 溶媒 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 生成物 | 1-Benzenesulfonyl-4-(2'-chloro-5'-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one | HCID 44548211 | — |
反応手順
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 2-chloro-5-fluorophenylboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-4-(2′-chloro-5′-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one as a light yellow oil. MS: 472.9 ([M+H]+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063088B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-ed4a196afb274e9eac278dfd0ac6aa61 |
| 出典メモ | uspto-grants-2011_11 |