化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Carbonate → 1-Benzenesulfonyl-4-(5'-fluoro-2'-methoxy-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 5-Fluoro-2-methoxyphenylboronic acid | HCID 2782673 | — |
| 反応物 | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 溶媒 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 生成物 | 1-Benzenesulfonyl-4-(5'-fluoro-2'-methoxy-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one | HCID 44548390 | — |
反応手順
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 5-fluoro-2-methoxyphenylboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-4-(5′-fluoro-2′-methoxy-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one as an off-white solid. MS: 469.2 ([M+H]+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063088B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-9409c2d0dba44395bc915615ae9d6011 |
| 出典メモ | uspto-grants-2011_11 |