6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde → 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

HRID 560305ノート

反応式

HRID 560305 の反応式
Cl([O-])=O.[Na+].[OH2:5].O.P([O-])(O)(O)=O.[Na+].[Cl:13][C:14]1[N:15]=[C:16]2[N:20]([C:21]=1[CH:22]=[O:23])[CH:19]=[CH:18][S:17]2>O.C(O)(C)(C)C>[Cl:13][C:14]1[N:15]=[C:16]2[N:20]([C:21]=1[C:22]([OH:5])=[O:23])[CH:19]=[CH:18][S:17]2

参加物

6

反応物 3

HCID 3299506-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehydeHCID 23668197Sodium ChloriteHCID 23673460Sodium Phosphate, Monobasic, Dihydrate

生成物 1

HCID 3299776-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6386tert-Butanol溶媒

実験手順

A solution of sodium chlorite (230 mmol) and sodium dihydrogen phosphate dihydrate (176 mmol) in water (195 mL) is added dropwise to a solution of 6-chloro-imidazo[2,1-b]thiazole-5-carbaldehyde (26.8 mmol) in tert.-butanol (195 mL) and the mixture is stirred for 8 h at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off. The filtrate is made acidic and the obtained precipitate is filtered off to give the desired product as a white solid.

後処理

  1. customThe solvents are partially removed in vacuo
  2. filtrationthe obtained precipitate is filtered off
  3. filtrationthe obtained precipitate is filtered off

出典と根拠

ORDレコード
ord-a4c2b60627294f8090a8f0ede8077b7c
出典データセット
uspto-grants-2011_11
特許番号
US08063099B2

反応ノート

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