Allyl bromide → 3-allyloxy-4-fluoro-benzoic Acid Ethyl Ester

HRID 560316ノート

反応式

HRID 560316 の反応式
C([O-])([O-])=O.[K+].[K+].Br[CH2:8][CH:9]=[CH2:10].[CH2:11]([O:13][C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([OH:22])[CH:16]=1)[CH3:12]>CC(C)=O>[CH2:11]([O:13][C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([O:22][CH2:10][CH:9]=[CH2:8])[CH:16]=1)[CH3:12]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 18007712Ethyl 4-fluoro-3-hydroxybenzoate

生成物 1

HCID 669987353-allyloxy-4-fluoro-benzoic Acid Ethyl Ester

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

K2CO3 (96.9 mmol) and 3-bromo-1-propen (64.6 mmol) are added to a solution of 4-fluoro-3-hydroxy-benzoic acid ethyl ester (32.3 mmol) in acetone (50 mL). The mixture is heated to reflux for 16 h, filtered and cooled to RT. The solvents are removed in vacuo to give the desired product which is used without further purification. LC-MS: tR=1.01 min; [M+CH3CN+H]+=266.0.

後処理

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 16 h
  3. filtrationfiltered
  4. customThe solvents are removed in vacuo

出典と根拠

ORDレコード
ord-b0f29086079d4af2aca10cfe0353505d
出典データセット
uspto-grants-2011_11
特許番号
US08063099B2

反応ノート

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