Triphenylphosphine → HCID 55283830、化合物

HRID 560566ノート

反応式

HRID 560566 の反応式
[N:1]([CH2:4][C:5]1[O:6][C:7]([CH:10]([F:12])[F:11])=[CH:8][CH:9]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1.O>[F:11][CH:10]([F:12])[C:7]1[O:6][C:5]([CH2:4][NH2:1])=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 11776TriphenylphosphineHCID 866452892-(Azidomethyl)-5-(difluoromethyl)furan

生成物 1

HCID 55283830HCID 55283830、化合物収率 70%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-(azidomethyl)-5-(difluoromethyl)furan (0.50 g, 2.92 mmol) in a mixture of tetrahydrofuran (10 mL) and water (1 mL) was added triphenylphosphine (1.15 g, 4.39 mmol). The reaction mixture was stirred at ambient temperature for 18 hours. The solvent was removed in vacuo and the residue was purified on strong cation exchange column to afford (5-(difluoromethyl)furan-2-yl)methanamine as a yellow oil in 70% yield (0.30 g): MS (ES+) m/z 3148.2 (M+1).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified on strong cation exchange column

出典と根拠

ORDレコード
ord-b9762b1229464556805a9b28919527cb
出典データセット
uspto-grants-2011_11
特許番号
US08063084B2

反応ノート

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