Ethyl 1-cyclopentyl-6,7-difluoro-8-methoxy-5-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate → Ethyl 1-cyclopentyl-6,7-difluoro-8-methoxy-5-amino-1,4-dihydro-4-oxoquinoline-3-carboxylate
反応式
[CH:1]1([N:6]2[C:15]3[C:10](=[C:11]([N+:20]([O-])=O)[C:12]([F:19])=[C:13]([F:18])[C:14]=3[O:16][CH3:17])[C:9](=[O:23])[C:8]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1>CCO.CN(C=O)C.[Pd]>[CH:1]1([N:6]2[C:15]3[C:10](=[C:11]([NH2:20])[C:12]([F:19])=[C:13]([F:18])[C:14]=3[O:16][CH3:17])[C:9](=[O:23])[C:8]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1参加物
4
実験手順
A solution of 16 (6.0 g, 15 mmol) in EtOH-DMF (4:1, v/v, 250 mL) was hydrogenated under atmospheric pressure over 10% Pd/C (600 mg) at room temperature overnight. The catalyst was removed by filtration over Celite and the filtrate was concentrated in vacuo to dryness to yield 17 (5.0 g, 90%) which was used crude in the next step.