Trifluoroacetic acid → 4-[2-(Trifluoromethyl)phenoxy]piperidine

HRID 561188

反応式

HRID 561188 の反応式
FC(F)(F)C(O)=O.[F:8][C:9]([F:31])([F:30])[C:10]1[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=1[O:12][CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1>C(Cl)Cl>[F:31][C:9]([F:8])([F:30])[C:10]1[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=1[O:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 46941590Tert-butyl 4-(2-(trifluoromethyl)phenoxy)piperidine-1-carboxylate

生成物 1

HCID 50187904-[2-(Trifluoromethyl)phenoxy]piperidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (26.3 mL, 342 mmol) was added to a solution of tert-butyl 4-[2-(trifluoromethyl)phenoxy]piperidine-1-carboxylate (29.5 g, 85 mmol) in CH2Cl2 (171 mL). The mixture was stirred at room temperature for 16 h. The solvent was removed by evaporation. The residue was diluted with EtOAc (200 mL), washed with 2 N NaOH (3×100 mL), brine, dried over Na2SO4, and evaporated to give the title compound as an oil.

後処理

  1. customThe solvent was removed by evaporation
  2. additionThe residue was diluted with EtOAc (200 mL)
  3. washwashed with 2 N NaOH (3×100 mL), brine
  4. dry with materialdried over Na2SO4
  5. customevaporated

出典と根拠

ORDレコード
ord-651f15b3e36345b1b0a76ac5aa3df6c0
出典データセット
uspto-grants-2011_11
特許番号
US08063224B2

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