Ammonium Hydroxide → 5-Bromo-1,3,4-thiadiazole-2-carboxamide
反応式
[Br:1][C:2]1[S:6][C:5]([C:7]([O:9]CC)=O)=[N:4][N:3]=1.[NH4+:12].[OH-]>C1COCC1>[Br:1][C:2]1[S:6][C:5]([C:7]([NH2:12])=[O:9])=[N:4][N:3]=1参加物
4
実験手順
To a solution of ethyl 5-bromo-1,3,4-thiadiazole-2-carboxylate (13.5 g, 56.9 mmol) in THF (50 mL) at room temperature was added NH4OH (28 wt. %, 39.6 mL, 164 mmol). The mixture was stirred at room temperature overnight and a precipitate appeared in the aqueous layer. Volatile materials were removed in vacuo. The mixture was diluted with water and the precipitate was collected, washed with water and dried under vacuum to give the title compound. 1H NMR (400 MHz, acetone-d6): δ7.99 (s, 1H), 7.55 (s, 1H).
後処理
- customVolatile materials were removed in vacuo
- additionThe mixture was diluted with water
- customthe precipitate was collected
- washwashed with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-3f6697c223e34916bedf03631935459f
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063224B2
反応ノート
読み込み中…