Sodium Hydroxide → (2'-{4-[2-(Trifluoromethyl)phenoxy]piperidin-1-yl}-2,5'-bi-1,3-thiazol-4-yl)acetic acid

HRID 561204ノート

反応式

HRID 561204 の反応式
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:30]=[CH:29][CH:28]=[CH:27][C:4]=1[O:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[S:13][C:14]([C:17]3[S:18][CH:19]=[C:20]([CH2:22][C:23]([O:25]C)=[O:24])[N:21]=3)=[CH:15][N:16]=2)[CH2:8][CH2:7]1.[OH-].[Na+]>C1COCC1.CO>[F:32][C:2]([F:1])([F:31])[C:3]1[CH:30]=[CH:29][CH:28]=[CH:27][C:4]=1[O:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[S:13][C:14]([C:17]3[S:18][CH:19]=[C:20]([CH2:22][C:23]([OH:25])=[O:24])[N:21]=3)=[CH:15][N:16]=2)[CH2:8][CH2:7]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86620458Methyl (2'-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-2,5'-bi-1,3-thiazol-4-yl)acetate

生成物 1

HCID 24988883(2'-{4-[2-(Trifluoromethyl)phenoxy]piperidin-1-yl}-2,5'-bi-1,3-thiazol-4-yl)acetic acid

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

A mixture of methyl (2′-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-2,5′-bi-1,3-thiazol-4-yl)acetate (220 mg, 0.44 mmol) in THF/MeOH (4:1) (v/v) (5 mL) was treated with 1 N NaOH (1 mL, 1 mmol) and heated at reflux temperature for 2 h. Volatile materials were removed in vacuo. The residue was diluted with water, acidified with 1 N HCl and extracted with EtOAc. The EtOAc extract was washed twice with water, dried (Na2SO4) and concentrated to give the title compound as a yellow foam.

後処理

  1. temperatureheated
  2. temperatureat reflux temperature for 2 h
  3. customVolatile materials were removed in vacuo
  4. additionThe residue was diluted with water
  5. extractionextracted with EtOAc
  6. extractionThe EtOAc extract
  7. washwas washed twice with water
  8. dry with materialdried (Na2SO4)
  9. concentrationconcentrated

出典と根拠

ORDレコード
ord-70a5d77146bc4ac4ad52e6448b1e0aae
出典データセット
uspto-grants-2011_11
特許番号
US08063224B2

反応ノート

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