Methanol → HCID 438674、化合物

HRID 5613ノート

反応式

HRID 5613 の反応式
[NH2:1][CH:2]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+].CO>C(O)(=O)C>[NH2:1][CH:2]([C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[C:3]([OH:5])=[O:4]

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 11218231Ethyl 2-amino-2-(1H-indol-3-yl)acetate

生成物 1

HCID 438674HCID 438674、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 2 g of ethyl α-aminoindole-3-acetate, excess dilute NaOH solution, and a few mL of MeOH was stirred occasionally for 25 minutes. Since a solution had not been obtained, the mixture was heated on a steam bath for ten minutes. The resulting solution was allowed to stand at ambient temperature for 50 minutes. The solution was acidified with acetic acid. The solid which separated was collected by filtration and washed with H2O giving 1.50 g (86%) of the title compound as small buff plates, m.p. 217° (dec).

後処理

  1. customSince a solution had not been obtained
  2. temperaturethe mixture was heated on a steam bath for ten minutes
  3. customThe solid which separated
  4. filtrationwas collected by filtration
  5. washwashed with H2O giving 1.50 g (86%) of the title compound as small buff plates, m.p. 217° (dec)

出典と根拠

ORDレコード
ord-69fd0f6486c34ef8b949897a3d4dc910
出典データセット
uspto-grants-1993_09
特許番号
US05245046

反応ノート

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