N-bromobutanimide → tert-Butyl 7-(bromomethyl)-1H-indole-1-carboxylate
反応式
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][C:15]=2[CH3:17])[CH:10]=[CH:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:18]N1C(=O)CCC1=O>ClC(Cl)(Cl)Cl>[Br:18][CH2:17][C:15]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:16]=1[N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH:9]=[CH:10]2参加物
4
実験手順
200 mg (865 μmol) of the compound from Example 5A were introduced into 10 ml of tetrachloromethane, 169 mg (951 μmol) of N-bromosuccinimide were added, and the mixture was heated under reflux while irradiating with a sun lamp for 4 h. The residue after concentration was purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate gradient) to result in 168 mg (63% of theory) of the title compound.
後処理
- additionwere added
- temperaturethe mixture was heated
- temperatureunder reflux
- customwhile irradiating with a sun lamp for 4 h
- concentrationThe residue after concentration
- customwas purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate gradient)
出典と根拠
- ORDレコード
- ord-912f81984e2f4c23baff2ad2439fb508
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063234B2
反応ノート
読み込み中…