Dichloromethane → 3-Fluoro-4-(pyrrolidin-1-yl)aniline

HRID 56138ノート

反応式

HRID 56138 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1.C(Cl)Cl>[Pd].CO>[F:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[NH2:8]

参加物

5

反応物 2

HCID 6344DichloromethaneHCID 28721221-(2-Fluoro-4-nitrophenyl)pyrrolidine

生成物 1

HCID 65005243-Fluoro-4-(pyrrolidin-1-yl)aniline収率 88%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 1-(2-fluoro-4-nitrophenyl)pyrrolidine (1.60 g, 7.62 mmol) in mixed solvents of CH2Cl2 (20 mL) and MeOH (20 mL) was added catalyst Pd/C (0.16 g). The reaction was stirred at rt under H2 overnight, and filtered. The filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V) 5:1) to give the title compound as a white solid (1.20 g, 88%).

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo
  3. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V) 5:1)

出典と根拠

ORDレコード
ord-91a11532f7e34b58af46186517edeccc
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

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