4-Fluorobenzaldehyde → (4-Chloro-2-methylphenyl)(4-fluorophenyl)methanol

HRID 561421

反応式

HRID 561421 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9].[F:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=1.FC1C=CC(C(C2C=CC(C(F)(F)F)=CC=2)O)=CC=1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([CH:15]([C:14]2[CH:17]=[CH:18][C:11]([F:10])=[CH:12][CH:13]=2)[OH:16])=[C:3]([CH3:9])[CH:4]=1

参加物

4

反応物 3

HCID 680234-FluorobenzaldehydeHCID 844762-Bromo-5-chlorotolueneHCID 579773alpha-(4-Fluorophenyl)-4-(trifluoromethyl)benzenemethanol

生成物 1

HCID 58392095(4-Chloro-2-methylphenyl)(4-fluorophenyl)methanol

実験手順

The title compound was prepared starting from 1.00 g (4.87 mmol) of 2-bromo-5-chlorotoluene and 0.72 g (5.84 mmol) of 4-fluorobenzaldehyde in analogy to the synthesis of the compound from Example 80A. 0.64 g (52% of theory) of the title compound was obtained.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-bef130b1c5ae4c6dac3ab49c24c06c69
出典データセット
uspto-grants-2011_11
特許番号
US08063234B2

関連ノート

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