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3-[(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(4-Chloro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-[(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 44595236 | — |
| 反応物 | (4-Chloro-2-methylphenyl)(4-fluorophenyl)methanol | HCID 58392095 | — |
| 反応物 | 3-(2,4-Dichlorophenyl)-3-{5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol | HCID 58392305 | — |
| 生成物 | 3-[(4-Chloro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392293 | — |
反応手順
The title compound was prepared starting from 380 mg (2.14 mmol) of the compound from Example 8 and 591 mg (2.36 mmol) of the compound from Example 83A in analogy to the synthesis of the compound from Example 101. 307 mg (35% of theory) of the target compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08063234B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-b92aa700f6da47d08551886697dde726 |
| 出典メモ | uspto-grants-2011_11 |