3-chloro-N-(2-morpholinoethyl)-4-nitroaniline → 3-chloro-N1-(2-morpholinoethyl)benzene-1,4-diamine
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[N+:17]([O-])=O)[NH:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1>CCOC(C)=O.[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[CH:14]=[CH:15][C:16]=1[NH2:17]参加物
4
実験手順
To a solution of 3-chloro-N-(2-morpholinoethyl)-4-nitroaniline (3.50 g, 12.25 mmol) in EtOAc (60 mL) was added catalyst Pd/C (0.73 g). The reaction was stirred at rt under H2 overnight, then filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.
後処理
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-93ebbf072ed644d4967deae5a740e95e
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434695B2
反応ノート
読み込み中…