Ethyl Acetate → 2-fluoro-N1-(3-morpholinopropyl)benzene-1,4-diamine

HRID 56165ノート

反応式

HRID 56165 の反応式
[F:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.CCOC(C)=O>[Pd].CO>[F:1][C:2]1[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 29277432-fluoro-N-(3-morpholinopropyl)-4-nitroaniline

生成物 1

HCID 431684652-fluoro-N1-(3-morpholinopropyl)benzene-1,4-diamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 2-fluoro-N-(3-morpholinopropyl)-4-nitroaniline (1.78 g, 6.28 mmol) in mixed solvents of EtOAc (15 mL) and MeOH (15 mL) was added catalyst Pd/C (0.30 g). The reaction was stirred at rt under H2 for 2 h, then filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-60f431a2f98345b1b92c44836d7122b0
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

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