4-Morpholinebutanenitrile → 4-(Morpholin-4-yl)butan-1-amine

HRID 56168

反応式

HRID 56168 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].[O:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][C:16]#[N:17])[CH2:9][CH2:8]1>C1COCC1.O>[O:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH2:9][CH2:8]1

参加物

5

反応物 2

HCID 2945744-MorpholinebutanenitrileHCID 21226445Aluminium lithium hydride

生成物 1

HCID 2336114-(Morpholin-4-yl)butan-1-amine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

To anhydrous THF (70 mL) was added LiAlH4 (5.37 g, 142 mmol) in one portion. The mixture was stirred at 0° C. for 20 min, and a solution of 4-morpholinobutanenitrile (7.26 g, 47 mmol) in anhydrous THF (40 mL) was added dropwise. Upon the end of addition the mixture was refluxed for 4 h, then cooled to 0° C., diluted with water (20 mL) and filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

後処理

  1. additionUpon the end of addition the mixture
  2. temperaturewas refluxed for 4 h
  3. temperaturecooled to 0° C.
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-2c9a79470dd24e1c8cfc412f9d1e7bf0
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

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