Potassium Carbonate → 2-fluoro-N-(4-morpholinobutyl)-4-nitroaniline

HRID 56169

反応式

HRID 56169 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH2:3][CH2:2]1.F[C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:14]=1[F:22].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[F:22][C:14]1[CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=[CH:18][C:13]=1[NH:11][CH2:10][CH2:9][CH2:8][CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 2336114-(Morpholin-4-yl)butan-1-amine

生成物 1

HCID 1179660642-fluoro-N-(4-morpholinobutyl)-4-nitroaniline

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A suspension of 4-morpholinobutan-1-amine (0.63 g, 4.00 mmol), 1,2-difluoro-4-nitrobenzene (0.64 g, 4.00 mmol) and K2CO3 (1.10 g, 8.00 mmol) in acetonitrile (20 mL) was stirred at rt for 19 h under N2, then filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-3a675810b1134632b765617e574da304
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

関連ノート

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