Dimethyl Sulfoxide → HCID 59762233、化合物
反応式
Cl[CH2:2][C@@H:3]([OH:13])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1.[N-:14]=[N+:15]=[N-:16].[Na+].CS(C)=O>O>[N:14]([CH2:2][C@@H:3]([OH:13])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[N+:15]=[N-:16]参加物
5
反応条件
- 温度
- 80 °C
実験手順
A mixture of (S)-1-Chloro-3-(4-fluoro-phenoxy)-propan-2-ol (5.0 g, 24.5 mmol), sodium azide (3.19 g, 49.0 mmol) and DMSO (25 mL) was stirred at 80° C. for 6 h. Then the reaction mixture was poured into water (100 mL), extracted with hexane-Et2O (1:1) mixture (2×100 mL). Extracts were washed with brine (100 mL), dried over Na2SO4 and evaporated. The residue was dried under vacuum at RT. Colorless oil, 4.83 g (22.9 mmol, 93%).
後処理
- extractionextracted with hexane-Et2O (1:1) mixture (2×100 mL)
- washExtracts were washed with brine (100 mL)
- dry with materialdried over Na2SO4
- customevaporated
- customThe residue was dried under vacuum at RT
出典と根拠
- ORDレコード
- ord-01e58f36933e4bcaa2d8db7a9c81fa36
- 出典データセット
- uspto-grants-2011_11
- 特許番号
- US08063225B2
反応ノート
読み込み中…