反応式
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][C:8](O)=[O:9].B.N#N>C1COCC1>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][CH2:7][CH2:8][OH:9]参加物
5
実験手順
To a solution of 3-(tetrahydrofuran-2-yl)propanoic acid (11.5 g, 80.0 mmol) in anhydrous THF (200 mL) was added borane (160 mL, 160 mmol, 1 mol/L in THF) dropwise under N2 and the mixture was stirred at rt overnight. The reaction mixture was quenched with MeOH and concentrated in vacuo to give the title compound, which was used for next step without further purification.
後処理
- customThe reaction mixture was quenched with MeOH
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-7a75b33b4b474dd5a6abbe7fc9ad701c
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09434695B2
関連ノート
読み込み中…