4-(4-Nitro-2-(trifluoromethyl)phenyl)morpholine → 4-Morpholino-3-(trifluoromethyl)aniline

HRID 56233ノート

反応式

HRID 56233 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[C:6]([C:16]([F:19])([F:18])[F:17])[CH:5]=1)([O-])=O>[Pd].CO>[F:19][C:16]([F:17])([F:18])[C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[N:10]1[CH2:11][CH2:12][O:13][CH2:14][CH2:15]1)[NH2:1]

参加物

4

反応物 1

HCID 6128564-(4-Nitro-2-(trifluoromethyl)phenyl)morpholine

生成物 1

HCID 27713294-Morpholino-3-(trifluoromethyl)aniline収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 4-(4-nitro-2-(trifluoromethyl)phenyl)morpholine (5.0 g, 18.1 mmol), MeOH (20 mL) and Pd/C (500 mg, 10%) under H2 was stirred at rt overnight. The mixture was then filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=2:1) to give the title compound as a pale yellow solid (4.01 g, 90%).

後処理

  1. filtrationThe mixture was then filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=2:1)

出典と根拠

ORDレコード
ord-b221ea29da11454bb85eff65ee70b680
出典データセット
uspto-grants-2016_09
特許番号
US09434695B2

反応ノート

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