Ethyl Bromide → Butanoic acid, 2-ethyl-3-oxo-, methyl ester
反応式
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[CH2:9](Br)[CH3:10].C[O-].[Na+]>CO>[C:3]([CH:2]([CH2:9][CH3:10])[C:1]([O:7][CH3:8])=[O:6])(=[O:4])[CH3:5]参加物
5
実験手順
465 g of methyl acetoacetate and then 458 g of ethyl bromide were added under nitrogen to 720 g of 30% sodium methylate solution in 1200 ml of methanol. The reaction mixture was subsequently boiled at reflux. After distillation of the methanol the residue was poured on to ice-water. It was then extracted with n-hexane and water. The organic phases were combined and dried. After evaporation of the solvent and distillation there were obtained 328 g (56.9%) of methyl 2-acetylbutyrate, b.p. 77°-79°/15 Torr.
後処理
- temperatureat reflux
- distillationAfter distillation of the methanol the residue
- additionwas poured on to ice-water
- extractionIt was then extracted with n-hexane and water
- customdried
- customAfter evaporation of the solvent
- distillationdistillation there
出典と根拠
- ORDレコード
- ord-f9b363bf630049efa482b18098a1d4e7
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05245056
反応ノート
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