Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 562453ノート

反応式

HRID 562453 の反応式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[OH-].[Na+].[OH:11][CH:12]1[CH2:15][NH:14][CH2:13]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:14]2[CH2:15][CH:12]([OH:11])[CH2:13]2)[CH:7]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 709434,6-DichloropyrimidineHCID 15142903-Hydroxyazetidine

生成物 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

7.3 g (48.7 mmol) of 4,6-dichloropyrimidine are suspended in 140 ml of water, and 47 ml 1 N aqueous sodium hydroxide solution are added. 5.3 g (48.7 mmol) of 3-hydroxyazetidine are added, and the reaction mixture is stirred at 90° C. for 3 d. After cooling to RT, the reaction mixture is concentrated under reduced pressure and reacted further without further purification.

後処理

  1. temperatureAfter cooling to RT
  2. concentrationthe reaction mixture is concentrated under reduced pressure
  3. customreacted further without further purification

出典と根拠

ORDレコード
ord-9ac6158955864f2aa78d7c64f0ec1ce0
出典データセット
uspto-grants-2011_11
特許番号
US08067407B2

反応ノート

読み込み中…